The 2022 NFL season will begin with the matchup between the two Super Bowl contenders.

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Los Angeles will welcome the Buffalo Bills in for the first game.

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ESPN's Predictive Computer Model has released its pick for the matchup.

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ESPN gives the Rams a slight lead at 49.9 percent over Buffalo's 49.6 percent.

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While Vegas leans in the other direction, ESPN gives the Rams a slight edge.

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The Bills are currently listed as one of the Super Bowl champions.

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There is a lot of pressure on Josh Allen and the Bills to succeed in 2022.

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Allen is the prime favorite for the MVP Trophy and is set to win the Super Bowl.

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The Rams are looking to defend their title after a stellar postseason last year.

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