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Due to a back issue, the four-time Grand Slam winner withdrew from her first-round match.
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In a match against Estonian Kaya Kanepi, where she was down 7-6(4), 3-0, she withdrew.
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"I felt my back from the beginning of the match, and despite trying to move through it, I couldn't today," Osaka said.
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Prior to the event, Osaka has lost all three of their matches in the first or second round.
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This included losing to Coco Gauff in straight sets at the Mubadala Silicon Valley Classic last week.
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His first competition following his recovery from an Achilles ailment was the French Open.
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She had finished the Miami Open in early April with the greatest tournament performance of the year before that race.
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In the second round, Alize Cornet of France will oppose Andreescu.